Christopher Michael Grochowski
Assistant Professor
Positions
- Assistant Professor
-
HGSC: Faculty
ÌÇÐÄlogo
Houston, TX, US
Education
- BS from American University
- 05/2011 - Washington, District of Columbia, United States
- Biology, Religious Studies
- MS from Rowan University
- 05/2014 - Stratford, New Jersey, United States
- Biomedical Science
- PhD from ÌÇÐÄlogo
- 01/2022 - Houston, Texas, United States
- Postdoctoral Training at ÌÇÐÄlogo
- 07/2023 - Houston, Texas, United States
Professional Interests
- Complex genomic rearrangements (CGRs)
- Copy number variation (CNV)
- Genomic optical mapping and long-read sequencing technologies
- Genomic disorders
- Chromothripsis, chromoanasynthesis, and chromoplexy
Professional Statement
Christopher M. Grochowski is an Assistant Professor at the Human Genome Sequencing Center (HGSC) at ÌÇÐÄlogo, where he joined the faculty in 2023. His research is dedicated to understanding the genetic and genomic underpinnings of human disease, with a particular emphasis on complex genomic rearrangements (CGRs), copy number variation (CNV), and somatic mosaicism.
Trained in the laboratory of Dr. James R. Lupski, Dr. Grochowski has worked on the integration of cutting-edge technologies — including genomic optical mapping, long-read sequencing (PacBio and Oxford Nanopore), and droplet digital PCR — with classical cytogenetic and molecular methods to resolve structural variants to nucleotide-level resolution. His work has highlights the mechanisms driving chromothripsis, chromoanasynthesis, and chromoplexy events, and has advanced our understanding of mutational processes including FoSTeS/MMBIR, NAHR, NHEJ, and AAMR.
Trained in the laboratory of Dr. James R. Lupski, Dr. Grochowski has worked on the integration of cutting-edge technologies — including genomic optical mapping, long-read sequencing (PacBio and Oxford Nanopore), and droplet digital PCR — with classical cytogenetic and molecular methods to resolve structural variants to nucleotide-level resolution. His work has highlights the mechanisms driving chromothripsis, chromoanasynthesis, and chromoplexy events, and has advanced our understanding of mutational processes including FoSTeS/MMBIR, NAHR, NHEJ, and AAMR.
Websites
Selected Publications
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Pande S, Dawood M, Grochowski CM. " " Genes (Basel). 2025 Jul ; 16 (8)
Pubmed PMID: . -
Grochowski CM, Gibbs RA, Doddapaneni H. " " Curr Protoc. 2024 May ; 4 (5) : e1041.
Pubmed PMID: . -
Grochowski CM, Du H, Mehaffey MG, et al. " " Cell Genom. 2024 Jul ; 4 (7)
Pubmed PMID: . -
CM Grochowski, ACV Krepischi, J Eisfeldt, H Du, DR Bertola, D Oliveira, SS Costa, JR Lupski, A Lindstrand, CMB Carvalho. " " Front Genet. 2021 ;
Pubmed PMID: .
Memberships
- American Society of Human Genetics (ASHG)
- (01/2014)
- BCMPride
- Faculty Advisor
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