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Jason M. Karch

Karch

Jason M. Karch

Assistant Professor

Email

karch@bcm.edu

Positions

Assistant Professor
Integrative Physiology
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Houston, TX, US

Education

PhD from University of Cincinnati
11/2012 - Cincinnati, Ohio, United States
Cell and Cancer Biology
BA from Dakota Wesleyan University
05/2005 - Mitchell, South Dakota, United States
Biology
Postdoctoral Fellowship at Cincinnati Children's Hospital Medical Center
11/2018 - Cincinnati, Ohio, United States
Molecular Cardiology

Professional Interests

  • Cell Death
  • Heart Disease
  • Mitochondria
  • Necrosis
  • mPTP

Professional Statement

Aberrant cell death is a common thread that binds various human diseases such as ischemic injuries, degenerative diseases, many types of cancer, and aging. Further mechanistic detail of the cell death pathways during these disease states is needed to identify efficacious novel therapeutic targets to prevent or induce cell death as needed. Specifically, we are interested in defining the regulated necrotic cell death pathway that leads to cardiomyocyte death during an ischemic event.

Websites

Selected Publications

  • Patel P, Mendoza A, Robichaux DJ, Wang MC, Wehrens XH, Karch J. " " 2021 ;
    Pubmed PMID: .
  • Patel, P., Mendoza, A., Ramirez, D., Robichaux, D., Molkentin, J. D., & Karch, J.. " " ;
    Pubmed PMID: .
  • Mendoza, A., Patel, P., Robichaux, D., Ramirez, D., & Karch,. " " ;
    Pubmed PMID: .
  • Robichaux DJ, Harata M, Murphy E, Karch J. " " JMCC. 2022 ;
    Pubmed PMID: .

Memberships

American Heart Association

Funding

Molecular Regulation of Mitochondrial Permeability Transition and its Role in Regulated Necrosis
#R01HL150031
(07/01/2020 - 07/01/2030)
Grant funding from NIH/NHLBI

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