Dan L Duncan Comprehensive Cancer Center
ÌÇÐÄlogo
Houston, Texas, United States
Professor
ÌÇÐÄlogo
Charles C. Bell Professor
Molecular and Cellular Biology
Addresses
Department of Molecular and Cellular Biology (Office)
ÌÇÐÄlogo
One ÌÇÐÄlogo Plaza N610
Houston, TX, 77030
United States
Phone: (832) 215-9503 jrosen@bcm.edu
Education
BA from Williams College
01/1966
- Williamstown, Massachusetts, United States
PhD from State University of New York at Buffalo
01/1970
- Buffalo, New York, United States
Post-Doctoral Fellowship at Vanderbilt University School of Medicine
01/1972
- Nashville, Tennessee, United States
Honors & Awards
Marc Dresden Excellence in Graduate Education Award, 1996
Endocrine Society Edwin B. Astwood Lecture Award 2000
Barbara & Corbin J. Robertson, Jr. Presidential Award for Excellence in Education, ÌÇÐÄlogo, 2002
Michael E. DeBakey, M.D., Excellence in Research Award, 2004.
Susan G. Komen for the Cure® Brinker Basic Science Award, 2010
AAAS Fellow, 2016
AACR Distinguished Lectureship in Breast Cancer Research, 2017
AACR/SABCS William A McGuire Memorial Lecture Award
AACR/SABCS
(12/2022)
Professional Interests
Developmental and hormonal regulation of mammary gland gene expression and breast cancer
Professional Statement
Our laboratory has developed a series of extensively characterized and "credentialed" syngeneic models of triple negative breast cancer that are being used in preclinical studies to determine both tumor intrinsic and extrinsic effects on the tumor microenvironment of both targeted therapies using small molecular inhibitors as well as gapmer antisense oligonucleotides. These studies are focused on combinatorial treatment strategies with standard-of care chemotherapy and immunotherapy of both primary tumors and established metastases with the long-term goal of translating these studies into the clinic.
Kim, IS, Welte, T, Gao, Y, Toneff, MJ, Wang, H, Janghorban, M, Zhao, N, Goldstein, A, Sheng, K, Niu, Y, Liu, J, Lo, H-C, Bado, I, Nguyen, T, et al. and Rosen, JM, Zhang, X H-F.. "
"
Nature Cell Biol.
2019 ;
21 : 1113-1126.
Pubmed PMID:
.
Nguyen, TM, Kabotyanski, EB, Dou, Y, Reineke, LC, Zhang, P, Zhang, X, Malovannaya, A, Jung, SY, Mo, Q, Roarty, K, Chen, Y, Zhang, B, Neilson, JR, Lloyd, RE, Perou, CM, Ellis, MJ and Rosen, JM.. "
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Cancer Res.
2018 ;
78 : 4229-4240.
Pubmed PMID:
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Sreekumar A, Toneff MJ, Toh E, Roarty K, Creighton CJ, Belka GK, Lee DK, Xu J, Chodosh LA, Richards JS, Rosen JM. "
"
Dev Cell.
2017 ;
43 : 436-448.
Pubmed PMID:
.
Welte, T., Kim, IS, Tian, L, Gao, X, Wang, H., Li, J. Holdman, X.B., Herschkowitz, J.I., Pond, A., Xie, G., Kurley, S, Nguyen, T, et al and Westbrook, T, Rosen, JM. and Zhang, XH. "
"
Nature Cell Biol.
2016 ;
18 : 632-644.
Pubmed PMID:
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Zhang, M, Tsimelzon, A, Chang, C-H, Fan, C., Wolff, A, Perou, CM, Hilsenbeck, SG and Rosen, JM. "
"
Cancer Discovery.
2015 ;
5 : 520-533.
Pubmed PMID:
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Roarty, K, Shore, AN, Creighton, CJ, and Rosen, JM. "
"
J Cell Biol.
2015 ;
208 : 351-366.
Pubmed PMID:
.
Hollier BG, Tinnirello AA, Werden SJ, Evans KW, Taube JH, Sarkar TR, Sphyris N, Shariati M, Kumar SV, Battula VL, Herschkowitz JI, Guerra R, Chang JT, Miura N, Rosen JM, Mani SA. "
"
Cancer Res..
2013 Mar 15;
73 (6) : 1981-92.
Pubmed PMID:
.
Machado HL, Kittrell FS, Edwards D, White AN, Atkinson RL, Rosen JM, Medina D, Lewis MT. "
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Stem Cells Transl Med.
2013 Mar ;
2 (3) : 199-203.
Pubmed PMID:
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Rosen JM. "
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Cold Spring Harb Perspect Biol.
2012 ;
4 (2)
Pubmed PMID:
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Shahi P, Park D, Pond AC, Seethammagari M, Chiou SH, Cho K, Carstens JL, Decker WK, McCrea PD, Ittmann MM, Rosen JM, Spencer DM. "
"
PLoS ONE.
2012 ;
7 (1) : e30814.
Pubmed PMID:
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Rosen JM. "
"
Cold Spring Harb Perspect Biol.
2012 ;
4 (4)
Pubmed PMID:
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Shore AN, Kabotyanski EB, Roarty K, Smith MA, Zhang Y, Creighton CJ, Dinger ME, Rosen JM. "
"
PLoS Genet..
2012 Jul ;
8 (7) : e1002840.
Pubmed PMID:
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Contreras A, Hale TK, Stenoien DL, Rosen JM, Mancini MA, Herrera RE. "
"
Mol. Cell. Biol..
2003 Dec ;
23 (23) : 8626-36.
Pubmed PMID:
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Rainusso N, Brawley VS, Ghazi A, Hicks MJ, Gottschalk S, Rosen JM, Ahmed N. "
"
Cancer Gene Ther..
2012 Mar ;
19 (3) : 212-7.
Pubmed PMID:
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Wei Z, Peddibhotla S, Lin H, Fang X, Li M, Rosen JM, Zhang P. "
"
Mol. Cell. Biol..
2011 Apr ;
31 (7) : 1470-7.
Pubmed PMID:
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Visbal AP, Lamarca HL, Villanueva H, Toneff MJ, Li Y, Rosen JM, Lewis MT. "
"
Dev. Biol..
2011 Apr 1;
352 (1) : 116-27.
Pubmed PMID:
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Meerbrey KL, Hu G, Kessler JD, Roarty K, Li MZ, Fang JE, Herschkowitz JI, Burrows AE, Ciccia A, Sun T, Schmitt EM, Bernardi RJ, Fu X, Bland CS, Cooper TA, Schiff R, Rosen JM, Westbrook TF, Elledge SJ. "
"
Proc. Natl. Acad. Sci. U.S.A..
2011 Mar 1;
108 (9) : 3665-70.
Pubmed PMID:
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Creighton CJ, Li X, Landis M, Dixon JM, Neumeister VM, Sjolund A, Rimm DL, Wong H, Rodriguez A, Herschkowitz JI, Fan C, Zhang X, He X, Pavlick A, Gutierrez MC, Renshaw L, Larionov AA, Faratian D, Hilsenbeck SG, Perou CM, Lewis MT, Rosen JM, Chang JC. "
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Proc. Natl. Acad. Sci. U.S.A..
2009 Aug 18;
106 (33) : 13820-5.
Pubmed PMID:
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Zhang M, Behbod F, Atkinson RL, Landis MD, Kittrell F, Edwards D, Medina D, Tsimelzon A, Hilsenbeck S, Green JE, Michalowska AM, Rosen JM. "
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Cancer Res..
2008 Jun 15;
68 (12) : 4674-82.
Pubmed PMID:
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Li X, Lewis MT, Huang J, Gutierrez C, Osborne CK, Wu MF, Hilsenbeck SG, Pavlick A, Zhang X, Chamness GC, Wong H, Rosen J, Chang JC. "
"
J. Natl. Cancer Inst..
2008 May 7;
100 (9) : 672-9.
Pubmed PMID:
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Xian W, Pappas L, Pandya D, Selfors LM, Derksen PW, de Bruin M, Gray NS, Jonkers J, Rosen JM, Brugge JS. "
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Cancer Res..
2009 Mar 15;
69 (6) : 2244-51.
Pubmed PMID:
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Vargo-Gogola, T and Rosen, JM. "
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Nature Rev Cancer.
2007 ;
7 : 659-672.
Pubmed PMID:
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Heckman BM, Chakravarty G, Vargo-Gogola T, Gonzales-Rimbau M, Hadsell DL, Lee AV, Settleman J, Rosen JM. "
"
Dev. Biol..
2007 Sep 1;
309 (1) : 137-49.
Pubmed PMID:
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