Jessica Karch
Assistant Professor
Positions
- Assistant Professor
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Integrative Physiology
ÌÇÐÄlogo
Houston
Education
- BS from Syracuse University
- 05/2009 - Syracuse
- PhD from Rutgers University- New Jersey Medical School
- 10/2015 - Newark
Professional Statement
The overall goal of my research program is to define the molecular mechanisms that link major risk factors, including hypertension, diabetes, and obesity, to the development and progression of cardiovascular disease and failure. Our laboratory seeks to identify these molecular pathways and their alterations in response to chronic stressors, with the ultimate goal of developing novel therapeutic strategies for cardiovascular disease.
Current areas of interest include defining the mechanisms of cardiac insulin resistance; investigating the role of stress-responsive proteins in cardiac physiology (exercise, pregnancy, and insulin sensitivity) and pathology (hypertension, ischemic injury, and insulin resistance); and defining the mechanisms of insulin-dependent cardiac circadian clock entrainment, as well as their disruption in insulin resistance and contribution to cardiac disease. Together, these studies aim to identify the molecular changes that drive cardiac dysfunction and uncover new therapeutic targets for the treatment of heart disease.
Current areas of interest include defining the mechanisms of cardiac insulin resistance; investigating the role of stress-responsive proteins in cardiac physiology (exercise, pregnancy, and insulin sensitivity) and pathology (hypertension, ischemic injury, and insulin resistance); and defining the mechanisms of insulin-dependent cardiac circadian clock entrainment, as well as their disruption in insulin resistance and contribution to cardiac disease. Together, these studies aim to identify the molecular changes that drive cardiac dysfunction and uncover new therapeutic targets for the treatment of heart disease.
Websites
Selected Publications
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Pfleger J, Gross P, Johnson J, Gao E, Houser SR, Koch WJ. " " J Mol Cell Cardiol. 2018 Oct ;
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Pfleger J, Gresham K, Koch WJ. " " Nat Rev Cardiol. 2019 Jun ;
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Pfleger J, Coleman RC, Ibetti J, Roy R, Kyriazis ID, Gao E, Drosatos K, Koch WJ. " " Circulation. 2020 Sep ;
Pubmed PMID: . -
Pfleger J, He M, Abdellatif M. " " Cell Death Dis. 2015 Jul 30;
Pubmed PMID: .
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