Stem Cell Adaptation to Stress
Adult stem cells encounter a wide range of physiological challenges throughout life, including inflammation, infection, tissue injury, and aging. We investigate how these stressors alter hematopoietic stem cell function and determine whether adaptive responses promote tissue regeneration or contribute to stem cell dysfunction. Our goal is to define the molecular mechanisms that enable stem cells to maintain lifelong blood production while preserving their regenerative capacity.
Clonal Hematopoiesis and Aging
Clonal hematopoiesis arises when hematopoietic stem cells acquire mutations that confer a competitive advantage, leading to the expansion of mutant blood cell clones during aging. We study the cellular and molecular mechanisms that drive clonal expansion and influence disease progression. By understanding how mutant stem cells outcompete normal stem cells, we aim to identify strategies to prevent the development of age-associated disorders and hematologic malignancies.
Diet, Metabolism and Clonal Hematopoiesis
Diet is a major environmental determinant of metabolism and health during aging. We investigate how nutritional and metabolic signals influence hematopoietic stem cell fitness and modify the progression of clonal hematopoiesis. In particular, we seek to understand how diet interacts with somatic mutations to promote or restrain clonal expansion and how these interactions contribute to metabolic diseases and other age-related disorders. Our ultimate goal is to identify dietary and metabolic interventions that improve health outcomes.
Leukemic Stem Cells and Therapeutic Vulnerabilities
Leukemia is sustained by stem-like malignant cells that possess abnormal self-renewal capacity and resistance to conventional therapies. We investigate the mechanisms that enable leukemic stem cells to survive, proliferate, and evade differentiation. By identifying pathways that are selectively required for leukemic stem cell function, we aim to develop therapeutic approaches that eradicate cancer while preserving normal hematopoiesis.